Generic Name: typhoid vaccine, live (Oral route)
TYE-foid VAX-een, lyve
Commonly used brand name(s)
In the U.S.
- Vivotif
Available Dosage Forms:
- Capsule, Delayed Release
- Capsule
Therapeutic Class: Vaccine
Uses For Vivotif
Typhoid fever is a serious disease that can cause death. It is caused by a germ called Salmonella typhi, and is spread most often through infected food or water. Typhoid may also be spread by close person-to-person contact with infected persons (such as occurs with persons living in the same household). Some infected persons do not appear to be sick, but they can still spread the germ to others.
Typhoid fever is very rare in the United States (U.S.) and other areas of the world that have good water and sewage (waste) systems. However, it is a problem in parts of the world that do not have such systems. If you are traveling to certain countries or remote areas, typhoid vaccine will help protect you from typhoid fever. The U.S. CDC recommends caution in the following areas of the world:
- Africa
- Asia
- Latin America
Typhoid vaccine taken by mouth helps prevent typhoid fever, but does not provide 100% protection. Therefore, it is very important to avoid infected persons and food and water that may be infected, even if you have taken the vaccine.
To get the best possible protection against typhoid, you should complete the vaccine dosing schedule (all 4 doses of the vaccine) at least 1 week before travel to areas where you may be exposed to typhoid.
If you will be traveling regularly to parts of the world where typhoid is a problem, you should get a booster (repeat) dose of the vaccine every 5 years.
Typhoid vaccine is available only from a health care professional.
Before Using Vivotif
In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Typhoid vaccine is not recommended for infants and children up to 6 years of age. Although there is no specific information comparing use of typhoid vaccine in children 6 years of age and over with use in other age groups, this vaccine is not expected to cause different side effects or problems in these children than it does in adults.
Geriatric
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of typhoid vaccine in the elderly with use in other age groups, this vaccine is not expected to cause different side effects or problems in older people than it does in younger adults.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breast Feeding
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aclarubicin
- Adalimumab
- Aldesleukin
- Altretamine
- Amonafide
- Amsacrine
- Asparaginase
- Azacitidine
- Azathioprine
- Bleomycin
- Broxuridine
- Busulfan
- Capecitabine
- Carboplatin
- Carmustine
- Certolizumab Pegol
- Chlorambucil
- Cisplatin
- Cladribine
- Cyclophosphamide
- Cytarabine
- Cytarabine Liposome
- Dacarbazine
- Dactinomycin
- Daunorubicin
- Daunorubicin Citrate Liposome
- Decitabine
- Docetaxel
- Doxifluridine
- Doxorubicin Hydrochloride
- Doxorubicin Hydrochloride Liposome
- Edatrexate
- Eflornithine
- Epirubicin
- Estramustine
- Etanercept
- Etoposide
- Everolimus
- Fingolimod
- Floxuridine
- Fludarabine
- Fluorouracil
- Fotemustine
- Gallium Nitrate
- Gemcitabine
- Golimumab
- Hydroxyurea
- Idarubicin
- Ifosfamide
- Irinotecan
- Lomustine
- Mechlorethamine
- Melphalan
- Mercaptopurine
- Methotrexate
- Mitolactol
- Mitomycin
- Mitotane
- Mitoxantrone
- Mycophenolic Acid
- Oxaliplatin
- Paclitaxel
- Pegaspargase
- Pentostatin
- Pipobroman
- Pirarubicin
- Plicamycin
- Procarbazine
- Raltitrexed
- Rilonacept
- Rituximab
- Sirolimus
- Streptozocin
- Tacrolimus
- Teceleukin
- Tegafur
- Temsirolimus
- Teniposide
- Thioguanine
- Thiotepa
- Topotecan
- Treosulfan
- Trimetrexate
- Trofosfamide
- Uracil Mustard
- Ustekinumab
- Vinblastine
- Vincristine
- Vincristine Liposome
- Vindesine
- Vinorelbine
Receiving this vaccine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abatacept
- Cytomegalovirus Immune Globulin, Human
- Leflunomide
- Vaccinia Immune Globulin, Human
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:
- Diarrhea or
- Fever or
- Other illness (severe) or
- Stomach or intestinal illness (severe) or
- Vomiting—These conditions may reduce the useful effect of the vaccine.
- Immune deficiency condition, including HIV or AIDS—May increase the chance of side effects from the vaccine.
Proper Use of Vivotif
It is important that all 4 doses of the vaccine be taken exactly as directed. If all the doses are not taken or if doses are not taken at the correct times, the vaccine may not work properly.
The vaccine capsules are meant to dissolve in the intestines. Therefore, they should be inspected to make sure that they are not broken or cracked when you take them. If any are broken or cracked, you will need to replace them.
Typhoid vaccine must be stored in the refrigerator at a temperature between 2 and 8 degrees C (35.6 and 46.4 degrees F) at all times. If the vaccine is left at room temperature, it will lose its effectiveness. Therefore, remember to replace unused vaccine in the refrigerator between doses.
Each dose of the vaccine should be taken approximately 1 hour before a meal. Take with a cold or lukewarm drink that has a temperature that does not exceed body temperature (eg, 37 degrees C or 98.6 degrees F).
Swallow the capsule whole. Do not chew it before swallowing. Also swallow the capsule as soon as possible after you place it in your mouth.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- Take 1 capsule by mouth every other day for a total of 4 doses.
Missed Dose
Call your doctor or pharmacist for instructions.
If you do not remember the missed dose until the next day, take the missed dose at that time and reschedule your every-other-day doses from then. It is important that this vaccine be taken exactly as directed so it can give you the most protection against typhoid fever.
Storage
Store in the refrigerator. Do not freeze.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using Vivotif
Tell all of your doctors that you have taken this vaccine if you plan to receive any other live vaccines within 1 month after the last dose.
If you are receiving this vaccine, do not take proguanil (Paludrine(R)) as a single medicine (not available in the United States) for at least 10 days after your last dose.
Vivotif Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Difficulty with breathing or swallowing
- hives
- itching, especially of the feet or hands
- reddening of the skin, especially around the ears
- swelling of the eyes, face, or inside of the nose
- unusual tiredness or weakness that is sudden and severe
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
- Diarrhea
- fever
- nausea
- skin rash
- stomach cramps or pain
- vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Vivotif side effects (in more detail)
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.
More Vivotif resources
- Vivotif Side Effects (in more detail)
- Vivotif Use in Pregnancy & Breastfeeding
- Vivotif Drug Interactions
- Vivotif Support Group
- 0 Reviews for Vivotif - Add your own review/rating
Compare Vivotif with other medications
- Typhoid Prophylaxis
